P2Y2R/GPR17 antagonist 1

Names

[ CAS No. ]:
2395016-49-4

[ Name ]:
P2Y2R/GPR17 antagonist 1

Biological Activity

[Description]:

P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y2R and GPR17 antagonist with IC50 values of 3.17 µM and 1.67 µM against P2Y2R and GPR17, respectively. P2Y2R/GPR17 antagonist 1 shows excellent metabolic stability in human liver microsomes[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> P2Y Receptor
Research Areas >> Inflammation/Immunology

[Target]

IC50: 1.67 µM (GPR17), 3.17 µM (P2Y2R)[1]


[References]

[1]. Pillaiyar T, et al. Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2Y2 and GPR17. Eur J Med Chem. 2020 Jan 15;186:111789.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H13ClN2O6S

[ Molecular Weight ]:
432.83

Related Compounds