AC-42

Names

[ Name ]:
AC-42

[Synonym ]:
AC 42
AC42

Biological Activity

[Description]:

AC-42 is a poent M1 muscarinic selective allosteric agonist with EC50s of 805 nM and 220 nM for human wild-type and Y381A mutated M1 receptors, respectively[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Signaling Pathways >> GPCR/G Protein >> mAChR

Research Areas >> Neurological Disease

[References]

[1]. Marlene A Jacobson, et al. The M1 muscarinic receptor allosteric agonists AC-42 and 1-[1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one bind to a unique site distinct from the acetylcholine orthosteric site. Mol Pharmacol. 2010 Oct;78(4):648-57.

Chemical & Physical Properties

[ Density]:
0.958±0.06 g/cm3(Predicted)

[ Boiling Point ]:
427.5±28.0 °C(Predicted)

[ Molecular Formula ]:
C₂₀H₃₁NO

[ Molecular Weight ]:
301.47

Related Compounds

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