244291-63-2

244291-63-2 structure

Name: AC-42
Chemical Name: AC-42
CAS Number: 244291-63-2
Molecular Formula: C₂₀H₃₁NO
Molecular Weight: 301.47
Catalog: Signaling Pathways GPCR/G Protein mAChR
Create Date: 2023-11-26 17:29:07
Modify Date: 2025-08-25 17:57:02
AC-42 is a poent M1 muscarinic selective allosteric agonist with EC50s of 805 nM and 220 nM for human wild-type and Y381A mutated M1 receptors, respectively[1].

Name	AC-42
Synonyms	AC 42 AC42

Description	AC-42 is a poent M1 muscarinic selective allosteric agonist with EC50s of 805 nM and 220 nM for human wild-type and Y381A mutated M1 receptors, respectively[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
References	[1]. Marlene A Jacobson, et al. The M1 muscarinic receptor allosteric agonists AC-42 and 1-[1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one bind to a unique site distinct from the acetylcholine orthosteric site. Mol Pharmacol. 2010 Oct;78(4):648-57.