BChE-IN-17

Names

[ Name ]:
BChE-IN-17

Biological Activity

[Description]:

BChE-IN-17 (compound 6n) is a potent and selective BChE inhibitor with IC50s of 10.5 nM and 32.5 nM for eqBChE and hBChE, respectively. BChE-IN-17 shows over 1000-fold selectivity to BChE against AChE. BChE-IN-17 shows low neurotoxicity and moderate neuroprotective effects[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

eqBCHE:10.5 nM (IC50)

hBCHE:32.5 nM (IC50)

eel AChE:686.4 μM (IC50)

[References]

[1]. Tingkai Chen, et al. The structural modification and biological evaluation of tetrahydrothienopyridine derivatives as selective BChE inhibitors. Bioorg Med Chem Lett. 2023 Sep 1;93:129436.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₃BrN₂O₄S₂

[ Molecular Weight ]:
535.47

Related Compounds

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