Aβ-IN-5

Names

[ CAS No. ]:
2417977-65-0

[ Name ]:
Aβ-IN-5

Biological Activity

[Description]:

Aβ-IN-5 (Compound e12) is an orally active Aβ aggregation inhibitor. Aβ-IN-5 also inhibits AChE and BuChE with IC50 values of 21.29 μM and 1.32 μM, respectively. Aβ-IN-5 shows excellent neuroprotective effects and low neurotoxicity[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

IC50: 1.32 μM (BuChE), 21.29 μM (AChE)[1]


[In Vitro]

Aβ-IN-5 (Compound e12) (25 μM) exhibits significant inhibition of Aβ aggregation with an inhibitory rate of 72%[1].

[In Vivo]

Aβ-IN-5 (Compound e12) (15 mg/kg; p.o.) restores learning and memory function and exhibits no acute toxicity in vivo[1].

[References]

[1]. Liao Q, et al. Design, synthesis and biological evaluation of novel carboline-cinnamic acid hybrids as multifunctional agents for treatment of Alzheimer's disease. Bioorg Chem. 2020 Jun;99:103844.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H20N2O3

[ Molecular Weight ]:
348.40

Related Compounds