<Suppliers Price>

CDK7-IN-6

Names

[ CAS No. ]:
2378710-04-2

[ Name ]:
CDK7-IN-6

Biological Activity

[Description]:

CDK7-IN-6 is a potent and selective cyclin-dependent kinase (CDK7) inhibitor (IC50≤100 nM), extracted from patent WO2019197549 A1, compound 210. CDK7-IN-6 is > 200-fold selective for CDK7 over CDK1, CDK2, and CDK5. CDK7-IN-6 can be used for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

CDK7:≤100 nM (IC50)


[In Vitro]

CDK7-IN-6 inhibits the viability of HCT116, H460, MV4-11, A2780, and OVCAR cells (IC50≤1 μM)[1].

[References]

[1]. Kiyean NAM, et al.Preparation of pyrazolotriazine and/or pyrazolopyrimidine derivatives as selective inhibitor of cyclin dependent kinase. WO2019197549 A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H34ClN9O

[ Molecular Weight ]:
524.06

Related Compounds