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CDK7-IN-7

Names

[ CAS No. ]:
2640208-01-9

[ Name ]:
CDK7-IN-7

Biological Activity

[Description]:

CDK7-IN-7 is a potent and selective CDK7 kinase inhibitor with an IC50 of <50 nM (Patent CN112661745A, compound T-01)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

CDK7:<50 nM (IC50)


[In Vitro]

CDK7-IN-7 shows inhibitory against MDA‑MB 231, MDA-MB453, OVCAR3, A2780, HCT-116, WiDr and Calu-6 cells (IC50 ranging from 12.21 to 144.9 nM)[1].

[References]

[1]. Compounds useful as CDK7 kinase inhibitors and uses thereof. CN112661745A.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H20BrF3N6O2

[ Molecular Weight ]:
513.31

Related Compounds