Mu opioid receptor antagonist 7

Names

[ CAS No. ]:
2378397-30-7

[ Name ]:
Mu opioid receptor antagonist 7

Biological Activity

[Description]:

Mu opioid receptor antagonist 7 (compound 24) is a potent and CNS permeable antagonist of µOR (µ-opioid receptor), with an IC50 of 29 ± 3.0 nM. Mu opioid receptor antagonist 7 can be used for the research of pain and opioid use disorder[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor
Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
Research Areas >> Neurological Disease

[Target]

μ Opioid Receptor/MOR:29 ± 3.0 nM (IC50)


[References]

[1]. Nerurkar A, et al. Novel series of tunable µOR modulators with enhanced brain penetration for the treatment of opioid use disorder, pain and neuropsychiatric indications. Bioorg Med Chem Lett. 2023 Aug 15;92:129405.  

Chemical & Physical Properties

[ Molecular Formula ]:
C22H27ClN2O2

[ Molecular Weight ]:
386.91

Related Compounds

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