RBN-3143

Names

[ Name ]:
RBN-3143

Biological Activity

[Description]:

RBN-3143 is a potent and selective PARP14 inhibitor with an IC50 value of 4 nM. RBN-3143 inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cell lines. RBN-3143 can be used in research of inflammation[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PARP

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

PARP14:4 nM (IC50)

PARP10:1600 nM (IC50)

PARP15:4200 nM (IC50)

PARP4:42700 nM (IC50)

PARP3:>100000 nM (IC50)

PARP2:>100000 nM (IC50)

PARP1:>100000 nM (IC50)

[In Vivo]

RBN-3143 (5 ug; 鼻内给药) 可改善类固醇耐药哮喘小鼠模型[1]。 Animal Model: Mouse of asthma models[1] Dosage: 5 ug Administration: Intranasal administration Result: Suppressed the accumulation of alarmins TSLP, IL-33, and IL-25.

[References]

[1]. Niepel M, et, al. The PARP14 inhibitor RBN-3143 suppresses lung inflammation in preclinical models. European Respiratory Journal 2022 60: 4642.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₈FN₃O₄S

[ Molecular Weight ]:
449.54

Related Compounds

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