PAC1R antagonist 1

Names

[ CAS No. ]:
2305204-24-2

[ Name ]:
PAC1R antagonist 1

Biological Activity

[Description]:

PAC1R antagonist 1 (compound 3d) is a potent and orally active antagonist of PAC1 receptor. PAC1R antagonist 1 can inhibit pituitary adenylate cyclase-activating polypeptide (PACAP)- and nerve injury-induced allodynia[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[References]

[1]. Takasaki I, et, al. Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain. Eur J Med Chem. 2020 Jan 15;186:111902.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H17ClN6O2

[ Molecular Weight ]:
372.81

Related Compounds