Top1 inhibitor 1

Names

[ CAS No. ]:
2302772-05-8

[ Name ]:
Top1 inhibitor 1

Biological Activity

[Description]:

Top1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC50 value of 29 nM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

[Target]

IC50: 29 nM (human topoisomerase I)[1]


[In Vitro]

Top1 inhibitor 1 reveals cytotoxicity in cancerous cells including MCF7 (IC50: 2.74 µM), HeLa (IC50: 2.61 µM), HCT116 (IC50: 2.34 µM), NIH: OVCAR-3 (IC50: 2.35 µM) cells compared to the non-cancerous cells like HEK293 (IC50: 8.34 µM) [1].

[References]

[1]. Kundu B, et al. Discovery and Mechanistic Study of Tailor-Made Quinoline Derivatives as Topoisomerase 1 Poison with Potent Anticancer Activity. J Med Chem. 2019 Apr 11; 62(7):3428-3446.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H22N6O2

[ Molecular Weight ]:
426.47

Related Compounds