2302772-05-8
2302772-05-8 structure
- Name: Top1 inhibitor 1
- Chemical Name: Top1 inhibitor 1
- CAS Number: 2302772-05-8
- Molecular Formula: C24H22N6O2
- Molecular Weight: 426.47
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
- Create Date: 2019-06-01 16:47:56
- Modify Date: 2024-01-02 17:05:38
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Top1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC50 value of 29 nM[1].
| Name | Top1 inhibitor 1 |
|---|
| Description | Top1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC50 value of 29 nM[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 29 nM (human topoisomerase I)[1] |
| In Vitro | Top1 inhibitor 1 reveals cytotoxicity in cancerous cells including MCF7 (IC50: 2.74 µM), HeLa (IC50: 2.61 µM), HCT116 (IC50: 2.34 µM), NIH: OVCAR-3 (IC50: 2.35 µM) cells compared to the non-cancerous cells like HEK293 (IC50: 8.34 µM) [1]. |
| References |
| Molecular Formula | C24H22N6O2 |
|---|---|
| Molecular Weight | 426.47 |