JAK3 covalent inhibitor-1

Names

[ CAS No. ]:
2300106-50-5

[ Name ]:
JAK3 covalent inhibitor-1

Biological Activity

[Description]:

JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs[1].

[Related Catalog]:

Signaling Pathways >> JAK/STAT Signaling >> JAK
Signaling Pathways >> Epigenetics >> JAK
Signaling Pathways >> Stem Cell/Wnt >> JAK
Research Areas >> Inflammation/Immunology

[Target]

JAK3:11 nM (IC50)


[References]

[1]. Casimiro-Garcia A, et al. Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors. J Med Chem. 2018 Dec 13;61(23):10665-10699.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H17FN6O2S

[ Molecular Weight ]:
448.47

Related Compounds