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c-Met inhibitor 1

Names

[ CAS No. ]:
1357072-61-7

[ Name ]:
c-Met inhibitor 1

[Synonym ]:
FD5012
3-[(2-Methyl-2H-indazol-5-yl)sulfanyl]-6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazine
6-(1-METHYL-1H-PYRAZOL-4-YL)-3-((2-METHYL-2H-INDAZOL-5-YL)THIO)-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZINE
1,2,4-Triazolo[4,3-b]pyridazine, 3-[(2-methyl-2H-indazol-5-yl)thio]-6-(1-methyl-1H-pyrazol-4-yl)-
c-Met inhibitor 1

Biological Activity

[Description]:

c-Met inhibitor 1 is an inhibitor of the c-Met receptor signaling pathway useful for the treatment of cancer including gastric, glioblastoma, and pancreatic cancer. IC50 value:Target: c-MetMore details please refer to Patent WO 2012015677 A1.

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR
Research Areas >> Cancer

[References]

[1]. PCT Int. Appl. (2012), WO 2012015677 A1 20120202.


[Related Small Molecules]

Capmatinib (INCB28060) | Foretinib (GSK1363089) | PHA-665752 | BMS-777607 | Dihexa | Savolitinib | Tivantinib (ARQ 197) | tepotinib | LY2801653 | SGX-523 | DCC-2618 | SU11274 | Ensartinib | CEP-40783 | JNJ-38877605

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C17H14N8S

[ Molecular Weight ]:
362.412

[ Exact Mass ]:
362.106201

[ PSA ]:
104.02000

[ LogP ]:
2.46

[ Index of Refraction ]:
1.838

[ Storage condition ]:
2-8℃

Related Compounds