(S)-Higenamine

Names

[ Name ]:
(S)-Higenamine

Biological Activity

[Description]:

(S)-Higenamine ((S)-Norcoclaurine) is the entry compound in benzylisoquinoline alkaloid biosynthesis. (S)-Higenamine is produced by the condensation of dopamine and 4-hydroxyphenylacetaldehyde (4-HPAA) by norcoclaurine synthase (NCS)[1].

[Related Catalog]:

Research Areas >> Others

[In Vitro]

The biosynthetic pathway leading to benzylisoquinoline alkaloids originates from the enzyme-catalyzed condensation of dopamine and 4-hydrophenylacetaldehyde to yield (S)-norcoclaurine. Both substrates are secondary metabolites derived from the decarboxylation/hydroxylation/deamination of tyrosine[1].

[References]

[1]. Minami H, et al. Functional analysis of norcoclaurine synthase in Coptis japonica. J Biol Chem. 2007;282(9):6274‐6282.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₇NO₃

[ Molecular Weight ]:
271.31100

[ Exact Mass ]:
271.12100

[ PSA ]:
72.72000

[ LogP ]:
2.56170

Related Compounds

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