(S)-Higenamine hydrobromide

Names

[ Name ]:
(S)-Higenamine hydrobromide

[Synonym ]:
6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-, (1S)-, hydrobromide (1:1)
(1S)-1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol hydrobromide (1:1)

Biological Activity

[Description]:

(S)-Higenamine ((S)-Norcoclaurine) hydrobromide, a S-enantiomer of Higenamine, is the entry compound in benzylisoquinoline alkaloid biosynthesis. (S)-Higenamine hydrobromide is produced by the condensation of dopamine and 4-hydroxyphenylacetaldehyde (4-HPAA) by norcoclaurine synthase (NCS)[1].

[Related Catalog]:

Research Areas >> Others

[Target]

Human Endogenous Metabolite

[In Vitro]

The biosynthetic pathway leading to benzylisoquinoline alkaloids originates from the enzyme-catalyzed condensation of dopamine and 4-hydrophenylacetaldehyde to yield (S)-norcoclaurine. Both substrates are secondary metabolites derived from the decarboxylation/hydroxylation/deamination of tyrosine[1].

[References]

[1]. Minami H, et al. Functional analysis of norcoclaurine synthase in Coptis japonica. J Biol Chem. 2007;282(9):6274‐6282.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₈BrNO₃

[ Molecular Weight ]:
352.223

[ Exact Mass ]:
351.046997

Related Compounds

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