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SD 2590 hydrochloride

Names

[ CAS No. ]:
226395-93-3

[ Name ]:
SD 2590 hydrochloride

[Synonym ]:
MFCD30182243
N-Hydroxy-1-(2-methoxyethyl)-4-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfonyl)-4-piperidinecarboxamide hydrochloride (1:1)
4-Piperidinecarboxamide, N-hydroxy-1-(2-methoxyethyl)-4-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]-, hydrochloride (1:1)
SD 2590 (hydrochloride)

Biological Activity

[Description]:

SD-2590 hydrochloride is a potent MMP inhibitor with IC50 values of ﹤0.1, ﹤0.1, 0.18, and 1.7 nM for MMP2, MMP13, MMP9, and MMP8, respectively. SD-2590 hydrochloride inhibits dilation of the left ventricle in rats[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Cardiovascular Disease
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[References]

[1]. Becker DP, et, al. Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease. J Med Chem. 2010 Sep 23;53(18):6653-80.  

Chemical & Physical Properties

[ Molecular Formula ]:
C22H26ClF3N2O7S

[ Molecular Weight ]:
554.96

[ Exact Mass ]:
554.110107

Related Compounds