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SD 1008

Names

[ CAS No. ]:
960201-81-4

[ Name ]:
SD 1008

Biological Activity

[Description]:

SD-1008 is a potent JAK inhibitor. SD-1008 inhibits tyrosyl phosphorylation of STAT3, JAK2 and Src. SD-1008 also reduces STAT3-dependent luciferase activity. SD-1008 enhances apoptosis induced by Paclitaxel in ovarian cancer cells via directly blocking the JAK-STAT3 signaling pathway[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> STAT
Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> JAK
Signaling Pathways >> Epigenetics >> JAK
Signaling Pathways >> Stem Cell/Wnt >> JAK
Signaling Pathways >> JAK/STAT Signaling >> STAT

[Target]

JAK2

STAT3


[References]

[1]. Duan Z, et al. 8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells. Mol Pharmacol. 2007;72(5):1137-1145.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H19NO5

[ Molecular Weight ]:
329.35

[ Exact Mass ]:
658.25300

[ PSA ]:
145.82000

[ LogP ]:
1.78920

Related Compounds