226395-93-3

226395-93-3 structure

Name: SD 2590 hydrochloride
Chemical Name: SD 2590 (hydrochloride)
CAS Number: 226395-93-3
Molecular Formula: C₂₂H₂₆ClF₃N₂O₇S
Molecular Weight: 554.96
Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
Create Date: 2021-06-03 18:02:03
Modify Date: 2024-01-12 18:07:02
SD-2590 hydrochloride is a potent MMP inhibitor with IC50 values of ﹤0.1, ﹤0.1, 0.18, and 1.7 nM for MMP2, MMP13, MMP9, and MMP8, respectively. SD-2590 hydrochloride inhibits dilation of the left ventricle in rats[1].

Name	SD 2590 (hydrochloride)
Synonyms	MFCD30182243 N-Hydroxy-1-(2-methoxyethyl)-4-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfonyl)-4-piperidinecarboxamide hydrochloride (1:1) 4-Piperidinecarboxamide, N-hydroxy-1-(2-methoxyethyl)-4-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]-, hydrochloride (1:1) SD 2590 (hydrochloride)

Description	SD-2590 hydrochloride is a potent MMP inhibitor with IC50 values of ﹤0.1, ﹤0.1, 0.18, and 1.7 nM for MMP2, MMP13, MMP9, and MMP8, respectively. SD-2590 hydrochloride inhibits dilation of the left ventricle in rats[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
References	[1]. Becker DP, et, al. Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease. J Med Chem. 2010 Sep 23;53(18):6653-80.