Antitumor agent-104

Names

[ Name ]:
Antitumor agent-104

Biological Activity

[Description]:

Antitumor agent-104 (Compound 9) is an antitumor agent by inhibiting DNA damage repair in tumors. Antitumor agent-104 inhibits PARP1 enzymatic activity and the PAR protein level. Antitumor agent-104 also inhibits the expression of CDK12[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> PARP

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[References]

[1]. Lin S, et al. Synthesis of Novel Dual Target Inhibitors of CDK12 and PARP1 and Their Antitumor Activities in HER2-Positive Breast Cancers. ACS Omega. 2023 Jul 7;8(28):25574-25581.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₁H₃₃FN₆O₃

[ Molecular Weight ]:
556.63