GSK-3 inhibitor 3

Names

[ Name ]:
GSK-3 inhibitor 3

Biological Activity

[Description]:

GSK-3 inhibitor 3 is a selective, orally active and brain-penetrant inhibitor of GSK-3, with IC50s of 0.35 nM and 0.25 nM for GSK-3α and GSK-3β, respectively. GSK-3 inhibitor 3 lowers levels of tau protein phosphorylation at S396 in a triple-transgenic mouse Alzheimer’s disease model, with IC50 of 10 nM. GSK-3 inhibitor 3 can be used for neurological disease research[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> GSK-3

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

Research Areas >> Neurological Disease

Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3

[Target]

GSK-3α:0.35 nM (IC50)

GSK-3β:0.25 nM (IC50)

CDK2:0.22 μM (IC50)

CDK5:1.3 μM (IC50)

[References]

[1]. Hartz RA, et.al. Discovery of 2-(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 (GSK-3) Inhibitors. J Med Chem. 2023 Jun 8;66(11):7534-7552.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₁₅FN₆O

[ Molecular Weight ]:
410.40

Related Compounds

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