3,4-Dihydro-7-hydroxy-2(1H)-quinolinone

Names

[ Name ]:
3,4-Dihydro-7-hydroxy-2(1H)-quinolinone

[Synonym ]:
2,7-quinolinediol, 3,4-dihydro-
3,4-Dihydro-7-hydroxycarbostyril
MFCD06410891
2(1H)-Quinolinone, 3,4-dihydro-7-hydroxy-
7-Hydroxy-2-oxo-1,2,3,4-tetrahydroquinoline
7-Hydroxy-3,4-dihydro-2(1H)-quinolinone
7-Hydroxy-3,4-dihydro-quinolin-2-one
7-Hydroxy-3,4-dihydrochinolin-2(1H)-on
7-hydroxy-3,4-dihydroquinolin-2(1H)-one
7-hydroxy-3,4-dihydro-2-quinolinone
7-Hydroxy-3,4-dihydro carbostyril
3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
7-hydroxy-3,4-dihydro-2(1H)quinolinone
Brexpiprazole Impurity 5
Aripiprazole - Impurity A
7-Hydroxy-3,4-dihydro-2(1H)-quinolinone

Biological Activity

[Description]:

7-Hydroxy-3,4-dihydro-2(1H)-quinolinone is a weak MAO-A inhibitor, with an IC50 of 183 μM, and has no effect on MAO-B[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Research Areas >> Neurological Disease

[Target]

IC50: 183 μM (MAO-A)[1]

[In Vitro]

7-Hydroxy-3,4-dihydro-2(1H)-quinolinone is a weak MAO-A inhibitor, with an IC50 of 183 μM, and has no effect on MAO-B[1].

[References]

[1]. Meiring L, et al. Inhibition of monoamine oxidase by 3,4-dihydro-2(1H)-quinolinone derivatives. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5498-502.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
403.7±45.0 °C at 760 mmHg

[ Melting Point ]:
233-237 °C

[ Molecular Formula ]:
C₉H₉NO₂

[ Molecular Weight ]:
163.173

[ Flash Point ]:
198.0±28.7 °C

[ Exact Mass ]:
163.063324

[ PSA ]:
49.33000

[ LogP ]:
0.99

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.604

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H317

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;Xn: Harmful;

[ Risk Phrases ]:
R22;R43

[ Safety Phrases ]:
S36/37

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Preparation

Customs

[ HS Code ]: 2933790090

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%