p-MPPI hydrochloride

Names

[ CAS No. ]:
220643-77-6

[ Name ]:
p-MPPI hydrochloride

[Synonym ]:
4-Iodo-N-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)benzamide monohydrochloride
P-Mppi HCl
p-MPPI hydrochloride
p-MPPI monohydrochloride

Biological Activity

[Description]:

p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT1A Receptor

[In Vitro]

p-MPPI hydrochloride has no agonist activity in both in vitro and in vivo tests of pre- and post-synaptic 5-HT1A receptor activity[1].

[In Vivo]

p-MPPI hydrochloride (0.5-4.5 mg/kg; i.p.) shows anxiolytic-like profile in the murine elevated plus-maze[2]. Animal Model: Adult male Swiss Webster mice (aged 8-9 weeks)[2] Dosage: 0.5, 1.5, 4.5 mg/kg Administration: i.p. Result: Produced a significant and dose-related anxiolytic profile on both conventional (open arm avoidance) and ethological (risk assessment) measures.

[References]

[1]. Sørensen E, et al. The selective 5-HT(1A) receptor antagonist p-MPPI antagonizes sleep--waking and behavioural effects of 8-OH-DPAT in rats. Behav Brain Res. 2001 Jun;121(1-2):181-7.

[2]. Cao BJ, et al. Anxiolytic-like profile of p-MPPI, a novel 5HT1A receptor antagonist, in the murine elevated plus-maze. Psychopharmacology (Berl). 1997 Feb;129(4):365-71.

Chemical & Physical Properties

[ Boiling Point ]:
657.5ºC at 760 mmHg

[ Molecular Formula ]:
C₂₅H₂₈ClIN₄O₂

[ Molecular Weight ]:
578.87300

[ Flash Point ]:
351.4ºC

[ Exact Mass ]:
578.09500

[ PSA ]:
48.91000

[ LogP ]:
4.96870

[ Vapour Pressure ]:
3.66E-17mmHg at 25°C

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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