lepomerine

Names

[ CAS No. ]:
22048-97-1

[ Name ]:
lepomerine

[Synonym ]:
1-Methyl-2-propyl-1H-chinolon-4
1-Methyl-2-propyl-1H-quinolin-4-one
1-methyl-2-propyl-1H-quinolin-4-one

Biological Activity

[Description]:

Leptomerine, an alkaloid from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer Disease. Leptomerine inhibits acetyl cholinesterase (AChE) with an IC50 of 2.5 μM. Anticholinesterasic activity[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> AChE

[References]

[1]. Cardoso-Lopes EM, et al. Alkaloids from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer disease. Molecules. 2010 Dec 13;15(12):9205-13.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₅NO

[ Molecular Weight ]:
201.26400

[ Exact Mass ]:
201.11500

[ PSA ]:
22.00000

[ LogP ]:
2.49100

Related Compounds

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