L-threonolactone

Names

[ Name ]:
L-threonolactone

[Synonym ]:
2,3-dihydroxydihydrofuran-1-one
Threonolactone
di-TMS-Threono-1,4-lactone
(3R,4S)-3,4-Dihydroxydihydrofuran-2(3H)-one
L-threonic acid-4-lactone
threonic acid-1,4-lactone
L-treono-1,4-lactone
L-Threonic acid-1,4-lactone
(3R,4S)-3,4-dihydroxyoxolan-2-one
Bis-TMS-Threono-1,4-lactone
L-Threonsaeure-4-lacton
(3R,4S)-3,4-dihydroxy-dihydrofuran-2-one

Biological Activity

[Description]:

L-Threonolactone ((3R,4S)-3,4-Dihydroxyoxolan-2-one) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
0.99g/cm3

[ Boiling Point ]:
277.8ºC at 760mmHg

[ Molecular Formula ]:
C₄H₆O₄

[ Molecular Weight ]:
118.09

[ Flash Point ]:
101.3ºC

[ Exact Mass ]:
118.02700

[ PSA ]:
66.76000

[ Vapour Pressure ]:
0.00443mmHg at 25°C

[ Index of Refraction ]:
1.437

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2932209090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

A convenient preparation of aldonohydroxamic acids in water and crystal structure of L-erythronohydroxamic acid.

Carbohydr. Res. 335(3) , 195-204, (2001)

Hydroxamic acids derived from aldonic acids, namely aldonohydroxamic acids, have become an increasingly important class of inhibitors of enzymes involved in the metabolism of carbohydrates. We now rep...

Alkaline and smith degradation of oxidized dermatan sulphate-chondroitin sulphate copolymers.

Carbohydr. Res. 36(2) , 349-58, (1974)

Metabolism of l-Threonic Acid in Rumex x acutus L. and Pelargonium crispum (L.) L'Hér.

Plant Physiol. 69(6) , 1365-8, (1982)

l-Threonic acid is a natural constituent in leaves of Pelargonium crispum (L.) L'Hér (lemon geranium) and Rumex x acutus L. (sorrel). In both species, l-[(14)C]threonate is formed after feeding l-[U-(...