TAK-070 Free base

Names

[ CAS No. ]:
212571-56-7

[ Name ]:
TAK-070 Free base

Biological Activity

[Description]:

TAK-070 Free base is a noncompetitive and orally active BACE1 inhibitor (IC50: 3.15 μM). TAK-070 Free base can be used for research of Alzheimer’s disease (AD). TAK-070 Free base inhibits brain levels of soluble Aβ, and improves cognitive impairments in AD model[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Beta-secretase
Research Areas >> Neurological Disease

[Target]

3.15 μM (BACE1)[1].


[References]

[1]. Fukumoto H, et al. A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease. J Neurosci. 2010 Aug 18;30(33):11157-66.  

Chemical & Physical Properties

[ Density]:
1.058±0.06 g/cm3(Predicted)

[ Boiling Point ]:
534.8±50.0 °C(Predicted)

[ Molecular Formula ]:
C27H31NO

[ Molecular Weight ]:
385.54

Related Compounds

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