212571-56-7

212571-56-7 structure

Name: TAK-070 Free base
Chemical Name: TAK-070
CAS Number: 212571-56-7
Molecular Formula: C₂₇H₃₁NO
Molecular Weight: 385.54
Catalog: Signaling Pathways Neuronal Signaling Beta-secretase
Create Date: 2023-10-29 18:14:48
Modify Date: 2024-01-28 11:02:00
TAK-070 Free base is a noncompetitive and orally active BACE1 inhibitor (IC50: 3.15 μM). TAK-070 Free base can be used for research of Alzheimer’s disease (AD). TAK-070 Free base inhibits brain levels of soluble Aβ, and improves cognitive impairments in AD model[1].

Name	TAK-070

Description	TAK-070 Free base is a noncompetitive and orally active BACE1 inhibitor (IC50: 3.15 μM). TAK-070 Free base can be used for research of Alzheimer’s disease (AD). TAK-070 Free base inhibits brain levels of soluble Aβ, and improves cognitive impairments in AD model[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Beta-secretase Research Areas >> Neurological Disease
Target	3.15 μM (BACE1)[1].
References	[1]. Fukumoto H, et al. A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease. J Neurosci. 2010 Aug 18;30(33):11157-66.