TAK-925

Names

[ Name ]:
TAK-925

Biological Activity

[Description]:

TAK-925 (Danavorexton) is a potent, selective, and brain-penetrant Orexin 2 receptor (OX2R) agonist with EC50 of 5.5 nM, no significant inhibition on OX1R (IC50>100 uM).TAK-925 also showed good selectivity against 106 off-target enzymes and receptors.TAK-925 produced wake-promoting effects in mice during the sleep phase, being developed for the treatment of narcolepsy and other related disorders.

[References]

1. Fujimoto T, et al. ACS Med Chem Lett. 2022 Feb 4;13(3):457-462. 2. Yukitake H, et al. Pharmacol Biochem Behav. 2019 Dec;187:172794.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₃₂N₂O₅S

[ Molecular Weight ]:
424.556

Related Compounds

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