2114324-48-8
2114324-48-8 structure
- Name: TAK-925
- Chemical Name: TAK-925
- CAS Number: 2114324-48-8
- Molecular Formula: C21H32N2O5S
- Molecular Weight: 424.556
- Create Date: 2022-07-02 19:22:33
- Modify Date: 2024-01-04 11:26:02
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TAK-925 (Danavorexton) is a potent, selective, and brain-penetrant Orexin 2 receptor (OX2R) agonist with EC50 of 5.5 nM, no significant inhibition on OX1R (IC50>100 uM).TAK-925 also showed good selectivity against 106 off-target enzymes and receptors.TAK-925 produced wake-promoting effects in mice during the sleep phase, being developed for the treatment of narcolepsy and other related disorders.
| Name | TAK-925 |
|---|
| Description | TAK-925 (Danavorexton) is a potent, selective, and brain-penetrant Orexin 2 receptor (OX2R) agonist with EC50 of 5.5 nM, no significant inhibition on OX1R (IC50>100 uM).TAK-925 also showed good selectivity against 106 off-target enzymes and receptors.TAK-925 produced wake-promoting effects in mice during the sleep phase, being developed for the treatment of narcolepsy and other related disorders. |
|---|---|
| References | 1. Fujimoto T, et al. ACS Med Chem Lett. 2022 Feb 4;13(3):457-462. 2. Yukitake H, et al. Pharmacol Biochem Behav. 2019 Dec;187:172794. |
| Molecular Formula | C21H32N2O5S |
|---|---|
| Molecular Weight | 424.556 |