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AT-121

Names

[ CAS No. ]:
2099681-31-7

[ Name ]:
AT-121

Biological Activity

[Description]:

AT-121 is a bifunctional nociception and mu opioid receptor agonist, with Kis of 3.67 and 16.49 nM, respectively. AT-121 is a safe, non-addictive analgesic, and shows antinociceptive and antiallodynic effects[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor
Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
Research Areas >> Neurological Disease

[In Vivo]

AT-121 (0.003-0.03 mg/kg; s.c.) produces potent antinociceptive effect[1]. Animal Model: Adult male and female rhesus monkeys[1] Dosage: 0.003-0.03 mg/kg Administration: Subcutaneous Result: Produced antinociceptive effects against an acute noxious stimulus, 50 °C water, in a dose-dependent.

[References]

[1]. Ding H, Kiguchi N, Yasuda D, et al. A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates. Sci Transl Med. 2018;10(456):eaar3483. doi:10.1126/scitranslmed.aar3483

Chemical & Physical Properties

[ Molecular Formula ]:
C24H38N4O3S

[ Molecular Weight ]:
462.65

Related Compounds