2′-O-2-Propyn-1-ylguanosine

Names

[ CAS No. ]:
206552-86-5

[ Name ]:
2′-O-2-Propyn-1-ylguanosine

[Synonym ]:
2'-O-2-Propyn-1-ylguanosine
Guanosine, 2'-O-2-propyn-1-yl-

Biological Activity

[Description]:

2′-O-2-Propyn-1-ylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
737.5±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₅N₅O₅

[ Molecular Weight ]:
321.29

[ Flash Point ]:
399.8±35.7 °C

[ Exact Mass ]:
321.107330

[ LogP ]:
0.31

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.761

Related Compounds

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