SL-651,498

Names

[ CAS No. ]:
205881-86-3

[ Name ]:
SL-651,498

Biological Activity

[Description]:

SL651498 is a full agonist of α2 and α3 GABAA receptors, and a partial agonist of α1 and α5 GABAA receptors. SL651498 shows anxiolytic and anticonvulsant activities[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[References]

[1]. G Griebel, et al. SL651498: an anxioselective compound with functional selectivity for alpha2- and alpha3-containing gamma-aminobutyric acid(A) (GABA(A)) receptors. J Pharmacol Exp Ther. 2001 Aug;298(2):753-68.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₀FN₃O₂

[ Molecular Weight ]:
389.42200

[ Exact Mass ]:
389.15400

[ PSA ]:
47.24000

[ LogP ]:
3.79540

Related Compounds

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