Meldrumic acid
Names
[ CAS No. ]:
2033-24-1
[ Name ]:
Meldrumic acid
[Synonym ]:
sub-Isopropyl malonate
MELDRUMS ACID
Malonic acid cyclic isopropylidene ester
Isopropyl Malonate
Meldrumacid
isopropylidene malonate
Meldrumic acid
Meldrum’s acid
1,3-Dioxane-4,6-dione, 2,2-dimethyl-
2,2-Dimethyl-1,3-dioxane-4,6-dione
cycl-Isopropylidene Malonate
2,2-Dimethyl-1,3-dio
MFCD00006638
2,2-Dimethyl-4,6-diketo-1,3-dioxane
EINECS 217-992-8
Meldrum acid
Biological Activity
[Description]:
[Related Catalog]:
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
356.7±35.0 °C at 760 mmHg
[ Melting Point ]:
92-96 °C(lit.)
[ Molecular Formula ]:
C6H8O4
[ Molecular Weight ]:
144.13
[ Flash Point ]:
195.1±24.4 °C
[ Exact Mass ]:
144.042252
[ PSA ]:
52.60000
[ LogP ]:
-1.40
[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C
[ Index of Refraction ]:
1.434
[ Storage condition ]:
0-6°C
[ Water Solubility ]:
2.5 g/100 mL (20 ºC)
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- JH0800000
- CHEMICAL NAME :
- m-Dioxane-4,6-dione, 2,2-dimethyl-
- CAS REGISTRY NUMBER :
- 2033-24-1
- BEILSTEIN REFERENCE NO. :
- 0117310
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C6-H8-O4
- MOLECULAR WEIGHT :
- 144.14
- WISWESSER LINE NOTATION :
- T6OV DVOTJ F1 F1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 180 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04102
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi,T
[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin . R45:May cause cancer.
[ Safety Phrases ]:
S37/39-S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
JH0800000
[ HS Code ]:
2934999090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2934999090
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Bioorg. Med. Chem. 18 , 5626-33, (2010)
A series of arylidene analogues of Meldrum's acid were synthesized and evaluated for in vitro antimalarial and antioxidant activities for the first time. The influence of various physico-chemical para...
One hundred years of Meldrum's acid: advances in the synthesis of pyridine and pyrimidine derivatives.Mol. Divers. 13(4) , 399-419, (2009)
A general review (138 references) focused on the recent advances in the application of Meldrum's acid reactivity for synthesis of diverse pyridine and pyrimidine derivatives, mostly small and drug-lik...
A new domino autocatalytic reaction leading to polyfunctionalized spiro[5.5]undecanes and dispiro[4.2.5.2]pentadecanes.Org. Biomol. Chem. 7(10) , 2195-201, (2009)
A new domino autocatalytic reaction of imines with Meldrum's acid was described. In this reaction, a series of polycyclic spiro[5.5]undecane-1,5,9-trione and dispiro[4.2.5.2]pentadecane-9,13-dione der...