Meldrumic acid

Names

[ CAS No. ]:
2033-24-1

[ Name ]:
Meldrumic acid

[Synonym ]:
sub-Isopropyl malonate
MELDRUMS ACID
Malonic acid cyclic isopropylidene ester
Isopropyl Malonate
Meldrumacid
isopropylidene malonate
Meldrumic acid
Meldrum’s acid
1,3-Dioxane-4,6-dione, 2,2-dimethyl-
2,2-Dimethyl-1,3-dioxane-4,6-dione
cycl-Isopropylidene Malonate
2,2-Dimethyl-1,3-dio
MFCD00006638
2,2-Dimethyl-4,6-diketo-1,3-dioxane
EINECS 217-992-8
Meldrum acid

Biological Activity

[Description]:

2,2-Dimethyl-1,3-dioxane-4,6-dione is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
356.7±35.0 °C at 760 mmHg

[ Melting Point ]:
92-96 °C(lit.)

[ Molecular Formula ]:
C₆H₈O₄

[ Molecular Weight ]:
144.13

[ Flash Point ]:
195.1±24.4 °C

[ Exact Mass ]:
144.042252

[ PSA ]:
52.60000

[ LogP ]:
-1.40

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.434

[ Storage condition ]:
0-6°C

[ Water Solubility ]:
2.5 g/100 mL (20 ºC)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JH0800000

CHEMICAL NAME :: m-Dioxane-4,6-dione, 2,2-dimethyl-

CAS REGISTRY NUMBER :: 2033-24-1

BEILSTEIN REFERENCE NO. :: 0117310

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C6-H8-O4

MOLECULAR WEIGHT :: 144.14

WISWESSER LINE NOTATION :: T6OV DVOTJ F1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04102

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi,T

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin . R45:May cause cancer.

[ Safety Phrases ]:
S37/39-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
JH0800000

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis and biological evaluation of arylidene analogues of Meldrum's acid as a new class of antimalarial and antioxidant agents.

Bioorg. Med. Chem. 18 , 5626-33, (2010)

A series of arylidene analogues of Meldrum's acid were synthesized and evaluated for in vitro antimalarial and antioxidant activities for the first time. The influence of various physico-chemical para...

One hundred years of Meldrum's acid: advances in the synthesis of pyridine and pyrimidine derivatives.

Mol. Divers. 13(4) , 399-419, (2009)

A general review (138 references) focused on the recent advances in the application of Meldrum's acid reactivity for synthesis of diverse pyridine and pyrimidine derivatives, mostly small and drug-lik...

A new domino autocatalytic reaction leading to polyfunctionalized spiro[5.5]undecanes and dispiro[4.2.5.2]pentadecanes.

Org. Biomol. Chem. 7(10) , 2195-201, (2009)

A new domino autocatalytic reaction of imines with Meldrum's acid was described. In this reaction, a series of polycyclic spiro[5.5]undecane-1,5,9-trione and dispiro[4.2.5.2]pentadecane-9,13-dione der...