Tenuifolin

Names

[ CAS No. ]:
20183-47-5

[ Name ]:
Tenuifolin

[Synonym ]:
(2β,3β)-3-(β-D-Glucopyranosyloxy)-2,27-dihydroxyolean-12-ene-24,28-dioic acid
Olean-12-ene-23,28-dioic acid, 3-(β-D-glucopyranosyloxy)-2,27-dihydroxy-, (2β,3β)-
Tenuifolin
Olean-12-ene-24,28-dioic acid, 3-(β-D-glucopyranosyloxy)-2,27-dihydroxy-, (2β,3β)-
(2β,3β)-3-(β-D-Glucopyranosyloxy)-2,27-dihydroxyolean-12-ene-23,28-dioic acid

Biological Activity

[Description]:

Tenuifolin is a triterpene isolated from Polygala tenuifolia Willd, has neuroprotective effects. Tenuifolin reduces Aβ secretion by inhibiting β-secretase. Tenuifolin improves learning and memory in aged mice by decreasing AChE activity and has the potential for Alzheimer’s disease (AD) treatment[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Beta-secretase

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

IC50: β-secretase; ACHE[1]

[References]

[1]. Ki-Yeol Yoo, et al. Terpenoids as Potential Anti-Alzheimer’s Disease Therapeutics. Molecules 2012, 17(3), 3524-3538

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
853.6±65.0 °C at 760 mmHg

[ Melting Point ]:
201-204℃

[ Molecular Formula ]:
C₃₆H₅₆O₁₂

[ Molecular Weight ]:
680.823

[ Flash Point ]:
262.2±27.8 °C

[ Exact Mass ]:
680.377197

[ PSA ]:
214.44000

[ LogP ]:
2.25

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.623

Safety Information

[ Safety Phrases ]:
24/25

[ HS Code ]:
29389090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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