UB 165 fumarate

Names

[ CAS No. ]:
200432-86-6

[ Name ]:
UB 165 fumarate

[Synonym ]:
Compound 401
UB 165 FUMARATE

Biological Activity

[Description]:

UB-165 is a nAChR agonist, being a full agonist of the α3β2 isoform and a partial agonist of the α4β2* isoform, with a Ki value of 0.27 nM for [3H]-nicotine binding in rat brain[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

Research Areas >> Neurological Disease

[In Vitro]

UB-165 刺激 [3H]-多巴胺从纹状体突触释放，EC50 值为 88 nM[1]。

[References]

[1]. Sharples CG, et al. UB-165: a novel nicotinic agonist with subtype selectivity implicates the alpha4beta2* subtype in the modulation of dopamine release from rat striatal synaptosomes. J Neurosci. 2000 Apr 15;20(8):2783-91.

Chemical & Physical Properties

[ Boiling Point ]:
597.4ºC at 760mmHg

[ Molecular Formula ]:
C₁₇H₁₉ClN₂O₄

[ Molecular Weight ]:
350.79700

[ Flash Point ]:
315.1ºC

[ Exact Mass ]:
350.10300

[ PSA ]:
99.52000

[ LogP ]:
3.07340

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.