Furanodiene

Names

[ CAS No. ]:
19912-61-9

[ Name ]:
Furanodiene

[Synonym ]:
cyclodeca(b)furan, 4,7,8,11-tetrahydro-3,6,10-trimethyl-, (5e,9z)-

Biological Activity

[Description]:

Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae. Furanodiene plays anti-cancer effects through anti-angiogenesis and inducing ROS production, DNA strand breaks and apoptosis. Furanodiene suppresseed efflux transporter Pgp (P-glycoprotein) function and reduced Pgp protein level[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein

[In Vitro]

Furanodiene (1.4, 4.1, 12.2 uM; 48 hours) is effective in treating human JF 305 pancreatic cancer cells and MCF-7 breast cancer cells xenotranplanted into the zebrafish[1]. Furanodiene has no effect on Pgp related gene (MDR1) expression[1].

[References]

[1]. Xiao-Yu Zhu, et al. Sensitization and synergistic anti-cancer effects of Furanodiene identified in zebrafish models. Sci Rep. 2019 Mar 14;9(1):4541.

Chemical & Physical Properties

[ Density]:
0.945±0.06 g/cm3

[ Boiling Point ]:
309.6±11.0 °C at 760 mmHg

[ Melting Point ]:
74-75 °C

[ Molecular Formula ]:
C₁₅H₂₀O

[ Molecular Weight ]:
216.31900

[ Exact Mass ]:
216.15100

[ PSA ]:
13.14000

[ LogP ]:
4.35940

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.