Furanodienone

Furanodienone is one of the major bioactive constituents derived from Rhizoma Curcumae. Furanodienone induced apoptosis[1].

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Furanodienone (0-573.8 μM; 24  hours) exhibits IC50 values : 56.4 μM (RKO), 73.7 μM (sw480), 251.1 μM (HT-29), 412.5 μM (sw620) and 573.8 μM (LoVo) at 24 hours, while that in 48 h are 51.8 μM (RKO), 44.18 μM (sw480), 168.9 μM (HT-29), 314.2 μM (sw620) and 502.1 μM (LoVo), respectively[1]. Furanodienone (0-150 μM; 24  hours) induces apoptosis and shows increase in caspase-9 and -3 activity has been observed in both cells, whereas a relative minor effect on that of caspase-8 in RKO and HT-29 cells[1]. Furanodienone (0-150 μM; 24  hours) increases the apoptotic rates from 2.34±0.45% to 19.45±2.37% and 27.34±0.79%, in RKO cells at 75 and 150 μM. whereas 12.4±1.08 and 20.64±3.02% apoptosis at the concentration of 75 and 150 μM are observed in HT-29 cells compared with 2.89±0.26%[1]. Western Blot Analysis[1] Cell Line: RKO and HT-29 cells Concentration: 0 μM; 50 μM; 100 μM; 150 μM Incubation Time: 24 hours Result: Increased caspase-9 and -3. Apoptosis Analysis[1] Cell Line: RKO and HT-29 cells Concentration: 0 μM; 75 μM; 150 μM Incubation Time: 24 hours Result: Induced apoptosis of colorectal cells (RKO and HT-29).

[1]. Li YW, et al. Furanodienone induces cell cycle arrest and apoptosis by suppressing EGFR/HER2 signaling in HER2-overexpressing human breast cancer cells. Cancer Chemother Pharmacol. 2011 Nov;68(5):1315-23.