19912-61-9

19912-61-9 structure

Name: Furanodiene
Chemical Name: furanodiene
CAS Number: 19912-61-9
Molecular Formula: C₁₅H₂₀O
Molecular Weight: 216.31900
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2016-07-09 08:58:18
Modify Date: 2024-01-05 13:20:27
Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae. Furanodiene plays anti-cancer effects through anti-angiogenesis and inducing ROS production, DNA strand breaks and apoptosis. Furanodiene suppresseed efflux transporter Pgp (P-glycoprotein) function and reduced Pgp protein level[1].

Name	furanodiene
Synonyms	cyclodeca(b)furan, 4,7,8,11-tetrahydro-3,6,10-trimethyl-, (5e,9z)-

Description	Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae. Furanodiene plays anti-cancer effects through anti-angiogenesis and inducing ROS production, DNA strand breaks and apoptosis. Furanodiene suppresseed efflux transporter Pgp (P-glycoprotein) function and reduced Pgp protein level[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein
In Vitro	Furanodiene (1.4, 4.1, 12.2 uM; 48 hours) is effective in treating human JF 305 pancreatic cancer cells and MCF-7 breast cancer cells xenotranplanted into the zebrafish[1]. Furanodiene has no effect on Pgp related gene (MDR1) expression[1].
References	[1]. Xiao-Yu Zhu, et al. Sensitization and synergistic anti-cancer effects of Furanodiene identified in zebrafish models. Sci Rep. 2019 Mar 14;9(1):4541.