Bleformin A

Names

[ CAS No. ]:
1980064-35-4

[ Name ]:
Bleformin A

Biological Activity

[Description]:

Bleformin A is a potent BChE inhibitor with an IC50 value of 5.2 μM. Bleformin A is a nature product that could be isolated from Bletilla striata. Bleformin A can be used for research of Alzheimer's disease (AD)[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> AChE

[In Vitro]

Bleformin A (compound 8; 0-8.302 μM) inhibits BChE with a Ki value of 4.7 μM. Bleformin A decreases Vmax and increases Km in a dose-dependent manner[1].

[References]

[1]. Liu Y, et, al. Biological evaluation, molecular modeling and dynamics simulation of phenanthrenes isolated from Bletilla striata as butyrylcholinesterase inhibitors. Sci Rep. 2022 Aug 11;12(1):13649.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₀O₅

[ Molecular Weight ]:
376.40

Related Compounds

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