AMPK-α1β1γ1 activator 1

Names

[ CAS No. ]:
1943510-86-8

[ Name ]:
AMPK-α1β1γ1 activator 1

Biological Activity

[Description]:

AMPK-α1β1γ1 activator 1 (M1) is an acyl glucuronide metabolite of Indole-3-carboxylic Acid-based AMPK activator. AMPK-α1β1γ1 activator 1 can selectively activated human β1 isoforms with an EC50 value of 38.1nM. AMPK-α1β1γ1 activator 1 can direct binding with human AMPK α1β1γ1 isoform. AMPK-α1β1γ1 activator 1 can be used for the research of diabetic nephropathy[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> AMPK

Research Areas >> Cardiovascular Disease

Signaling Pathways >> PI3K/Akt/mTOR >> AMPK

[Target]

EC50: 38.1nM (AMPK-α1β1γ1)[1]

[References]

[1]. Ryder TF, et al. Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK). J Med Chem. 2018 Aug 23;61(16):7273-7288.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₄ClNO₉

[ Molecular Weight ]:
517.91

Related Compounds

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