1943510-86-8

1943510-86-8 structure

Name: AMPK-α1β1γ1 activator 1
Chemical Name: AMPK-α1β1γ1 activator 1
CAS Number: 1943510-86-8
Molecular Formula: C₂₅H₂₄ClNO₉
Molecular Weight: 517.91
Catalog: Signaling Pathways Epigenetics AMPK
Create Date: 2023-12-22 11:07:04
Modify Date: 2024-01-03 12:50:30
AMPK-α1β1γ1 activator 1 (M1) is an acyl glucuronide metabolite of Indole-3-carboxylic Acid-based AMPK activator. AMPK-α1β1γ1 activator 1 can selectively activated human β1 isoforms with an EC50 value of 38.1nM. AMPK-α1β1γ1 activator 1 can direct binding with human AMPK α1β1γ1 isoform. AMPK-α1β1γ1 activator 1 can be used for the research of diabetic nephropathy[1].

Name	AMPK-α1β1γ1 activator 1

Description	AMPK-α1β1γ1 activator 1 (M1) is an acyl glucuronide metabolite of Indole-3-carboxylic Acid-based AMPK activator. AMPK-α1β1γ1 activator 1 can selectively activated human β1 isoforms with an EC50 value of 38.1nM. AMPK-α1β1γ1 activator 1 can direct binding with human AMPK α1β1γ1 isoform. AMPK-α1β1γ1 activator 1 can be used for the research of diabetic nephropathy[1].
Related Catalog	Signaling Pathways >> Epigenetics >> AMPK Research Areas >> Cardiovascular Disease Signaling Pathways >> PI3K/Akt/mTOR >> AMPK
Target	EC50: 38.1nM (AMPK-α1β1γ1)[1]
References	[1]. Ryder TF, et al. Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK). J Med Chem. 2018 Aug 23;61(16):7273-7288.

Molecular Formula	C₂₅H₂₄ClNO₉
Molecular Weight	517.91