DABCYL-γ-Abu-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2

Names

[ CAS No. ]:
193475-71-7

[ Name ]:
DABCYL-γ-Abu-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2

[Synonym ]:
tno211
dabcyl-(g-abu)-pqgl-e(edans)ak-nh2
mmp substrate iii,fluorogenic
dabcyl-gaba-pro-gln-gly-leu-glu(edans)-ala-lys-nh2
dabcyl-(g-abu)-pro-gln-gly-leu-glu(edans)-ala-lys-nh2
dabcyl-gaba-pqgl-e(edans)-ak-nh2
DABCYL-(γ-Abu)-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2

Biological Activity

[Description]:

TNO211 is a biological active peptide. (Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.This peptide is a highly soluble fluorogenic MMP substrate for MMP-2, 8, 12, 13 and 14, containing the MMP cleavable Gly-Leu bond and EDANS/DABCYL. Fluorogenic assays using TNO211 are sensitive and can detect MMP activity in culture medium from endothelial cells and untreated synovial fluid from patients. Abs/Em = 340/490 nm.)

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₃H₈₈N₁₆O₁₄S

[ Molecular Weight ]:
1325.54

[ Exact Mass ]:
1309.63000

[ PSA ]:
459.01000

[ LogP ]:
8.07790

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.