193475-71-7
193475-71-7 structure
- Name: DABCYL-γ-Abu-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2
- Chemical Name: DABCYL-(γ-Abu)-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2
- CAS Number: 193475-71-7
- Molecular Formula: C63H88N16O14S
- Molecular Weight: 1325.54
- Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
- Create Date: 2016-08-06 08:42:13
- Modify Date: 2024-01-12 19:31:02
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TNO211 is a biological active peptide. (Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.This peptide is a highly soluble fluorogenic MMP substrate for MMP-2, 8, 12, 13 and 14, containing the MMP cleavable Gly-Leu bond and EDANS/DABCYL. Fluorogenic assays using TNO211 are sensitive and can detect MMP activity in culture medium from endothelial cells and untreated synovial fluid from patients. Abs/Em = 340/490 nm.)
| Name | DABCYL-(γ-Abu)-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2 |
|---|---|
| Synonyms |
tno211
dabcyl-(g-abu)-pqgl-e(edans)ak-nh2 mmp substrate iii,fluorogenic dabcyl-gaba-pro-gln-gly-leu-glu(edans)-ala-lys-nh2 dabcyl-(g-abu)-pro-gln-gly-leu-glu(edans)-ala-lys-nh2 dabcyl-gaba-pqgl-e(edans)-ak-nh2 DABCYL-(γ-Abu)-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2 |
| Description | TNO211 is a biological active peptide. (Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.This peptide is a highly soluble fluorogenic MMP substrate for MMP-2, 8, 12, 13 and 14, containing the MMP cleavable Gly-Leu bond and EDANS/DABCYL. Fluorogenic assays using TNO211 are sensitive and can detect MMP activity in culture medium from endothelial cells and untreated synovial fluid from patients. Abs/Em = 340/490 nm.) |
|---|---|
| Related Catalog |
| Molecular Formula | C63H88N16O14S |
|---|---|
| Molecular Weight | 1325.54 |
| Exact Mass | 1309.63000 |
| PSA | 459.01000 |
| LogP | 8.07790 |