Stearoyl coenzyme A lithium

Names

[ CAS No. ]:
193402-48-1

[ Name ]:
Stearoyl coenzyme A lithium

[Synonym ]:
Adenosine, 5'-O-[hydroxy[[hydroxy[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-[[2-[(1-oxooctadecyl)thio]ethyl]amino]propyl]amino]butoxy]phosphinyl]oxy]phosphinyl]-, 3'-(dihydrogen phosphate), lithium salt (1:4)
n-Octadecanoyl Coenzyme A

Biological Activity

[Description]:

Stearoyl coenzyme A (Stearoyl-CoA) lithium is an active compound that can be used as a substrate for the determination of stearoyl-Coenzyme desaturase in microsomes[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. L D Lawson, et al. beta-Oxidation of the coenzyme A esters of elaidic, oleic, and stearic acids and their full-cycle intermediates by rat heart mitochondria. Biochim Biophys Acta. 1979 May 25;573(2):245-54.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₉H₆₆Li₄N₇O₁₇P₃S

[ Molecular Weight ]:
1034

[ Exact Mass ]:
1057.408936

[ Water Solubility ]:
Soluble in water.

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Stearoyl-CoA desaturase: a vital checkpoint in the development and progression of obesity.

Endocr. Metab. Immune Disord. Drug Targets 11 , 217-231, (2011)

Stearoyl-CoA desaturase 1 (SCD-1) is the rate-limiting enzyme that catalyses the conversion of saturated to monounsaturated fatty acids. Increased SCD-1 expression and activity has been implicated in ...

Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer.

Carcinogenesis 31 , 1509-1515, (2010)

As part of a shift toward macromolecule production to support continuous cell proliferation, cancer cells coordinate the activation of lipid biosynthesis and the signaling networks that stimulate this...

Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease.

PLoS ONE 6 , e24777, (2011)

The molecular bases of Alzheimer's disease (AD) remain unclear. We used a lipidomic approach to identify lipid abnormalities in the brains of subjects with AD (N = 37) compared to age-matched controls...