2'-Deoxyadenosine-5'-triphosphate

Names

[ CAS No. ]:
1927-31-7

[ Name ]:
2'-Deoxyadenosine-5'-triphosphate

[Synonym ]:
5'-DATP
DATP,LI
Disodium 2'-deoxy-5'-O-({[(phosphonooxy)phosphinato]oxy}phosphinato)adenosine
2'-Deoxy-ATP
deoxyribose adenosine triphosphate
Deoxyadenosine triphosphate
Adenosine, 2'-deoxy-, 5'-(tetrahydrogen triphosphate)
EINECS 217-662-3
2'-Deoxyadenosine-5'-triphosphate disodium salt
2'-Datp
2'-DEOXYADENOSINE-5'-TRIPHOSHATE
DATP LI-SALT
2'-Deoxyadenosine 5'-(tetrahydrogen triphosphate)
deoxyadenosinetriphosphate
deoxy-atp
[32P]-2'-Deoxyadenosine triphosphate
dATP
Adenosine, 2'-deoxy-, 5'-(tetrahydrogen triphosphate), sodium salt (1:2)
2'-Deoxyadenosine-5'-triphosphate
deoxyadenosine-triphosphate
2'-Deoxyadenosine 5'-triphosphate
MFCD00672265

Biological Activity

[Description]:

2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase[1].

[Related Catalog]:

Research Areas >> Others

[References]

[1]. P J Romaniuk, A study of the mechanism of T4 DNA polymerase with diastereomeric phosphorothioate analogues of deoxyadenosine triphosphate. J Biol Chem. 1982 Jul 10;257(13):7684-8.

Chemical & Physical Properties

[ Density]:
2.5±0.1 g/cm3

[ Boiling Point ]:
913.3±75.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₄N₅Na₂O₁₂P₃

[ Molecular Weight ]:
535.145

[ Flash Point ]:
506.1±37.1 °C

[ Exact Mass ]:
534.964722

[ PSA ]:
321.68000

[ LogP ]:
-4.93

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.874

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU7358800

CHEMICAL NAME :: Adenosine, 2'-deoxy-, 5'-(tetrahydrogen triphosphate)

CAS REGISTRY NUMBER :: 1927-31-7

BEILSTEIN REFERENCE NO. :: 0071964

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H16-N5-O12-P3

MOLECULAR WEIGHT :: 491.22

WISWESSER LINE NOTATION :: T56 BN DN FN HNT&J IZ D- ET5OTJ B1OPQO&OPQO&OPQQO CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 33600 nmol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 42,2092,1982

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
AU7358800

[ Packaging Group ]:
III

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

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Biochim. Biophys. Acta 1824(4) , 679-91, (2012)

The ribosome inactivating proteins (RIPs) of type 1 are plant toxins that eliminate adenine base selectively from the single stranded loop of rRNA. We report six crystal structures, type 1 RIP from Mo...

Mechanism and fidelity of HIV reverse transcriptase.

J. Biol. Chem. 267 , 25988-25997, (1992)

We have examined the RNA-dependent and DNA-dependent polymerase and ribonuclease H catalytic activities of human immunodeficiency virus reverse transcriptase using rapid transient kinetic methods with...

Human immunodeficiency virus reverse transcriptase: steady-state and pre-steady-state kinetics of nucleotide incorporation.

Biochemistry 31 , 4473-4479, (1992)

Steady-state and pre-steady-state kinetic constants were determined for reverse transcriptase catalyzed incorporation of nucleotides and nucleotide analogues into defined-sequence DNA primed-RNA templ...

Related Compounds

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