IACS-4619

Names

[ Name ]:
IACS-4619

Biological Activity

[Description]:

IACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.2 nM; shows no off-target kinase activity in a panel of 97 kinases; exhibits excellent cell permeability and good metabolic stability in microsomes; an excellent tool for interrogation of the utility of MTH1 inhibition in the context of oncology.

[References]

References 1. Petrocchi A, et al. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1503-7. View Related Products by Target DNA Repair Protein

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₇N₃O

[ Molecular Weight ]:
195.266

Related Compounds

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