IACS-4759
Names
[ CAS No. ]:
1884209-99-7
[ Name ]:
IACS-4759
Biological Activity
[Description]:
IACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.6 nM; shows no off-target kinase activity in a panel of 97 kinases; exhibits excellent cell permeability and good metabolic stability in microsomes; an excellent tool for interrogation of the utility of MTH1 inhibition in the context of oncology.
[References]
References 1. Petrocchi A, et al. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1503-7. View Related Products by Target DNA Repair Protein
Chemical & Physical Properties
[ Molecular Formula ]:
C10H17N3O2
[ Molecular Weight ]:
211.265