IACS-8803

Names

[ CAS No. ]:
2095690-70-1

[ Name ]:
IACS-8803

Biological Activity

[Description]:

IACS-8803 is a highly potent cyclic dinucleotide STING agonist with robust systemic antitumor efficacy[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> STING

[Target]

STING[1]


[In Vivo]

IACS-8803 shows a superior systemic anti-tumor response in the B16 murine model of melanoma[1].

[References]

[1]. Ager CR, et al. Discovery of IACS-8803 and IACS-8779, potent agonists of stimulator of interferon genes (STING) with robust systemic antitumor efficacy. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126640.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H23FN10O9P2S2

[ Molecular Weight ]:
692.53

Related Compounds