Butabindide
Names
[ CAS No. ]:
185213-03-0
[ Name ]:
Butabindide
[Synonym ]:
Butabindide oxalate
Nociceptin
Butabindide
Biological Activity
[Description]:
Butabindide (UCL-1397) oxalate is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide oxalate inhibits TPP II to protect CCK-8 against inactivation[1][2].
[Related Catalog]:
[Target]
IC50: 7 nM (TPP II) and 10 μM (TPP I)[1]
[In Vitro]
Butabindide (UCL-1397; 0-24 nM; membranes of rat cerebral cortex) oxalate inhibits TPP II activity of cerebral membranes[2].
[In Vivo]
Butabindide (UCL-1397; 10 mg/kg; i.v.; for 20 min) oxalate inhibits the breakdown of CCK-8 in the gastrointestinal tract and increases satiety in mice[2]. Animal Model: Mice (25-30 g)[2] Dosage: 10 mg/kg Administration: Intravenous injection; for 20 minutes Result: Reduces food intake and elicits other behavioral concomitants of satiation.
Chemical & Physical Properties
[ Molecular Formula ]:
C19H27N3O6
[ Molecular Weight ]:
393.43400
[ Exact Mass ]:
393.19000
[ PSA ]:
153.52000
[ LogP ]:
2.35910