Butabindide

Names

[ Name ]:
Butabindide

[Synonym ]:
Butabindide oxalate
Nociceptin
Butabindide

Biological Activity

[Description]:

Butabindide (UCL-1397) oxalate is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide oxalate inhibits TPP II to protect CCK-8 against inactivation[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[Target]

IC50: 7 nM (TPP II) and 10 μM (TPP I)[1]

[In Vitro]

Butabindide (UCL-1397; 0-24 nM; membranes of rat cerebral cortex) oxalate inhibits TPP II activity of cerebral membranes[2].

[In Vivo]

Butabindide (UCL-1397; 10 mg/kg; i.v.; for 20 min) oxalate inhibits the breakdown of CCK-8 in the gastrointestinal tract and increases satiety in mice[2]. Animal Model: Mice (25-30 g)[2] Dosage: 10 mg/kg Administration: Intravenous injection; for 20 minutes Result: Reduces food intake and elicits other behavioral concomitants of satiation.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₇N₃O₆

[ Molecular Weight ]:
393.43400

[ Exact Mass ]:
393.19000

[ PSA ]:
153.52000

[ LogP ]:
2.35910

Related Compounds

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