185213-03-0

185213-03-0 structure

Name: Butabindide
Chemical Name: (2S)-1-[(2S)-2-aminobutanoyl]-N-butyl-2,3-dihydroindole-2-carboxamide,oxalic acid
CAS Number: 185213-03-0
Molecular Formula: C₁₉H₂₇N₃O₆
Molecular Weight: 393.43400
Catalog: Research Areas Neurological Disease
Create Date: 2018-06-26 12:45:13
Modify Date: 2024-01-11 15:10:31
Butabindide (UCL-1397) oxalate is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide oxalate inhibits TPP II to protect CCK-8 against inactivation[1][2].

Name	(2S)-1-[(2S)-2-aminobutanoyl]-N-butyl-2,3-dihydroindole-2-carboxamide,oxalic acid
Synonyms	Butabindide oxalate Nociceptin Butabindide

Description	Butabindide (UCL-1397) oxalate is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide oxalate inhibits TPP II to protect CCK-8 against inactivation[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	IC50: 7 nM (TPP II) and 10 μM (TPP I)[1]
In Vitro	Butabindide (UCL-1397; 0-24 nM; membranes of rat cerebral cortex) oxalate inhibits TPP II activity of cerebral membranes[2].
In Vivo	Butabindide (UCL-1397; 10 mg/kg; i.v.; for 20 min) oxalate inhibits the breakdown of CCK-8 in the gastrointestinal tract and increases satiety in mice[2]. Animal Model: Mice (25-30 g)[2] Dosage: 10 mg/kg Administration: Intravenous injection; for 20 minutes Result: Reduces food intake and elicits other behavioral concomitants of satiation.